Nanoporous metal-phenolic particles as ultrasound imaging probes for hydrogen peroxide

Nanoporous metal–phenolic particles are fabricated through the nanostructural replication of dense Fe^III–TA complexes in nanoporous CaCO₃ template particles. The particles have potential for the diagnostic detection of endogenous levels of H₂O₂ ex vivo and in vivo by ultrasound imaging, which is based on the catalytic activity of the coordinated Fe³⁺ in the particles to break down H₂O₂ to O₂ microbubbles.