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Neocentromeres: new insights into centromere structure, disease development, and karyotype evolution

journal contribution
posted on 2023-05-18, 19:33 authored by Owen MarshallOwen Marshall, Chueh, AC, Wong, LH, Choo, KHA
Since the discovery of the first human neocentromere in 1993, these spontaneous, ectopic centromeres have been shown to be an astonishing example of epigenetic change within the genome. Recent research has focused on the role of neocentromeres in evolution and speciation, as well as in disease development and the understanding of the organization and epigenetic maintenance of the centromere. Here, we review recent progress in these areas of research and the significant insights gained.

History

Publication title

American Journal of Human Genetics

Volume

82

Pagination

261-282

ISSN

0002-9297

Department/School

Menzies Institute for Medical Research

Publisher

Univ Chicago Press

Place of publication

1427 E 60Th St, Chicago, USA, Il, 60637-2954

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the health sciences

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