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Nerve growth factor promotes olfactory axonal elongation
journal contributionposted on 2023-05-16, 13:47 authored by Martin, LV, Weston, S, Adrian WestAdrian West, Meng Inn ChuahMeng Inn Chuah
An explant culture system was used to test the effect of nerve growth factor (NGF) on olfactory axonal elongation. Statistical analysis showed that exogenously applied NGF (50 ng/ml) significantly enhanced olfactory neurite elongation from E14 rat olfactory epithelial explants (p = 0.025). Immunostaining showed that the neurites expressed activeTrkA receptors and that S-100-positive ensheathing cells were also present. In a separate experiment, immunoassay confirmed that following a growth period of 72 h, E14 presumptive olfactory bulb expressed and secreted NGF into the culture medium. The results indicate that during ontogeny, the olfactory bulb secretes NGF which binds to olfactory axons and facilitates their elongation. Â© 2002 Lippincott Williams & Wilkins.
Department/SchoolTasmanian School of Medicine
PublisherLippincott Williams & Wilkins
Place of publicationPhiladelphia