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Network modelling of gene regulation
journal contribution
posted on 2023-05-19, 11:03 authored by Ho, JWK, Michael CharlestonMichael CharlestonGene regulatory network (GRN) modelling has gained increasing attention in the past decade. Many computational modelling techniques have been proposed to facilitate the inference and analysis of GRN. However, there is often confusion about the aim of GRN modelling, and how a gene network model can be fully utilised as a tool for systems biology. The aim of the present article is to provide an overview of this rapidly expanding subject. In particular, we review some fundamental concepts of systems biology and discuss the role of network modelling in understanding complex biological systems. Several commonly used network modelling paradigms are surveyed with emphasis on their practical use in systems biology research.
History
Publication title
Biophysical ReviewsPagination
1-13ISSN
1867-2450Department/School
School of Natural SciencesPublisher
SpringerPlace of publication
GermanyRights statement
Copyright 2010 International Union for Pure and Applied Biophysics (IUPAB) and SpringerRepository Status
- Restricted