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Neural Responses to Masked Fear Faces: Sex Differences and Trauma Exposure in Posttraumatic Stress Disorder
journal contribution
posted on 2023-05-17, 07:08 authored by Kim FelminghamKim Felmingham, Kemp, AH, Peduto, A, Williams, LM, Liddell, B, Falconer, E, Bryant, RAlthough women have a greater propensity than men to develop posttraumatic stress disorder (PTSD) following trauma, sex differences in neural activations to threat have received little investigation. This study tested the prediction that trauma would heighten activity in automatic fear-processing networks to a greater extent in women than in men. Functional magnetic resonance imaging (fMRI) data were recorded in 23 participants with PTSD (13 women, 10 men), 21 trauma-exposed controls (9 women, 12 men), and 42 non-trauma-exposed controls (22 women, 20 men) while they viewed masked facial expressions of fear. Exposure to trauma was associated with enhanced brainstem activity to fear in women, regardless of the presence of PTSD, but in men, it was associated only with the development of PTSD. Men with PTSD displayed greater hippocampal activity to fear than did women. Both men and women with PTSD showed enhanced amygdala activity to fear relative to controls. The authors conclude that greater brainstem activation to threat stimuli may contribute to the greater prevalence of PTSD in women, and greater hippocampal activation in men may subserve an enhanced capacity for contextualizing fear-related stimuli.
History
Publication title
Journal of Abnormal PsychologyVolume
119Pagination
241-247ISSN
0021-843XDepartment/School
School of Psychological SciencesPublisher
Amer Psychological AssocPlace of publication
750 First St Ne, Washington, USA, Dc, 20002-4242Rights statement
Copyright © 2010 American Psychological AssociationRepository Status
- Restricted