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Neuroimaging in the field of psychoses

journal contribution
posted on 2023-05-17, 08:25 authored by Saxby PridmoreSaxby Pridmore, Bowe, G
This review looks at the recent findings in the neuroimaging of the psychoses, with a view to clarifying the question of the unitary versus the two-disorder theory of psychosis. Schizophrenia is associated with significantly more cortical grey matter loss than bipolar disorder. The distribution of these losses is different; schizophrenia is characteristically associated with loss of the medial and middle frontal, the superior temporal gyri, and the dorsolateral prefrontal cortex, while bipolar disorder has particular loss in the medial frontal gyrus and the anterior cingulate cortex. Both disorders were associated with extensive white matter deficits. In summary, neuroimaging indicates different patterns of grey matter loss for schizophrenia and bipolar disorder. However, neuroimaging of white matter reveals a good deal of overlap between these two disorders. Thus, neuroimaging does not suggest a unitary psychosis or a two-psychosis model, instead it suggests a two-dimensional psychosis field, on which disorders are located according to two dimensions, the degree of grey matter loss and the degree of white matter abnormality.

History

Publication title

Malaysian Journal of Medical Science

Volume

18

Pagination

6-11

ISSN

1394-195X

Department/School

Tasmanian School of Medicine

Publisher

Universiti Sains Malaysia

Place of publication

Malaysia

Rights statement

Copyright 2011 Penerbit Universiti Sains Malaysia

Repository Status

  • Restricted

Socio-economic Objectives

Mental health

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