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Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain
journal contributionposted on 2023-05-17, 03:07 authored by Howells, C, Adrian WestAdrian West, Chung, RS
Neuronal growth-inhibitory factor, later renamed metallothionein-3, is one of four members of the mammalian metallothionein family. Metallothioneins are a family of ubiquitous, low-molecular-weight, cysteine-rich proteins. Although neuronal growth-inhibitory factor shares metal-binding and reactive oxygen species scavenging properties with the other metallothioneins, it displays several distinct biological properties. In this review, we examine the recent developments regarding the function of neuronal growth-inhibitory factor within the brain, particularly in response to brain injury or during neurodegenerative disease progression.
Publication titleThe F E B S Journal
Department/SchoolMenzies Institute for Medical Research
PublisherWiley-Blackwell Publishing Ltd.
Place of publicationUnited Kingdom
Rights statementThe definitive published version is available online at: http://interscience.wiley.com