File(s) under permanent embargo
Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins
journal contribution
posted on 2023-05-17, 11:39 authored by Adrian WestAdrian West, Jacqueline LeungJacqueline Leung, Chung, RSMetallothionein has a well-documented pro- tective and proregenerative effect in the mammalian brain, particularly following physical trauma and ischemia or during the onset of neurodegenerative disease. A range of mechanisms have been established for this, including metallothionein�s metal binding properties and its ability to scavenge free radicals. In recent years it has become apparent that metallothionein is present in the extracellular compartment of the central nervous system and that it can interact with cell surface receptors of the lipoprotein- receptor-related protein family, including lipoprotein- receptor-related protein 1 (LRP1) and megalin. These interactions activate intracellular pathways which are consistent with many of the observed effects of metallo- thionein in the central nervous system, including its effects on neurons, glial cells, and cells of the immune system. The evidence describing the release, receptor interactions, and subsequent physiological consequences of metallothi- onein is discussed in this review.
History
Publication title
Journal of Biological Inorganic ChemistryVolume
16Issue
7Pagination
1115-1122ISSN
0949-8257Department/School
Menzies Institute for Medical ResearchPublisher
SpringerPlace of publication
GermanyRights statement
Copyright 2011 SBICRepository Status
- Restricted