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New chiral stationary phase with macrocyclic glycopeptide Z-D antibiotic eremomycin chemically bonded to silica
journal contributionposted on 2023-05-16, 20:05 authored by Staroverov S, SM, Kuznetsov, MA, Nesterenko, PN, Vasiarov, GG, Katruha, GS, Fedorova, GB
A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity. Â© 2006 Elsevier B.V. All rights reserved.
Publication titleJournal of Chromatography A
Department/SchoolSchool of Natural Sciences
Place of publicationNetherlands