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Nitroxide-loaded hexosomes provide MRI contrast in vivo
journal contributionposted on 2023-05-19, 13:15 authored by Nicole ByeNicole Bye, Hutt, OE, Hinton, TM, Acharya, DP, Waddington, LJ, Moffat, BA, Wright, DK, Wang, HX, Mulet, X, Muir, BW
The purpose of this work was to synthesize and screen, for their effectiveness to act as T1-enhancing magnetic resonance imaging (MRI) contrast agents, a small library of nitroxide lipids incorporated into cubic-phase lipid nanoparticles (cubosomes). The most effective nitroxide lipid was then formulated into lower-toxicity lipid nanoparticles (hexosomes), and effective MR contrast was observed in the aorta and spleen of live rats in vivo. This new class of lower-toxicity lipid nanoparticles allowed for higher relaxivities on the order of those of clinically used gadolinium complexes. The new hexosome formulation presented herein was significantly lower in toxicity and higher in relaxivity than cubosome formulations previously reported by us.
Department/SchoolSchool of Pharmacy and Pharmacology
PublisherAmer Chemical Soc
Place of publicationUnited States
Rights statementCopyright © 2014 American Chemical Society