File(s) under permanent embargo
No relationship between low density lipoproteins and endothelial function in hemodialysis patients
journal contribution
posted on 2023-05-16, 15:04 authored by Dalton, BS, Fassett, RG, Dominic Geraghty, De Ryke, R, Coombes, JSBackground: Relationships between low-density lipoprotein cholesterol and endothelial function in hemodialysis patients have yet to be investigated. Furthermore, current reporting of endothelial function data using flow-mediated dilatation has recognised limitations. The aims of the study were to determine the relationship between low-density lipoproteins and endothelial function in hemodialysis patients and to investigate the validity of determining the area under the curve for data collected during the flow-mediated dilatation technique. Methods: Brachial artery responses to reactive hyperemia (endothelial-dependent) and glyceryl trinitrate (endothelial-independent) were assessed in 19 hemodialysis patients using high-resolution ultrasound. Lipid profiles and other factors known to effect brachial artery reactivity were also measured prior to the flow-mediated dilatation technique. Results: There were no significant relationships between serum low-density lipoproteins and endothelial-dependent or -independent vasodilation using absolute change (mm), relative change (%), time to peak change (s) or area under the curve (mm·s). In hemodialysis patients with atherosclerosis, area under the curve analysis showed a significantly (p<0.05) decreased endothelial-dependent response (mean±S.D.: 19.2±17.4) compared to non-atherosclerotic patients (42.3±28.6). However, when analysing these data using absolute change, relative change or time to peak dilatation, there were no significant differences between the two groups. Conclusions: In summary, there was no relationship between low-density lipoproteins and endothelial function in hemodialysis patients. In addition, area under the curve analysis of flow-mediated vasodilatation data may be a useful method of determining the temporal vascular response during the procedure.
History
Publication title
International Journal of CardiologyVolume
99Pagination
307-314ISSN
0167-5273Department/School
School of Health SciencesPublisher
ElsevierPlace of publication
Republic of IrelandRights statement
The definitive version is available at http://www.sciencedirect.comRepository Status
- Restricted