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Normal values of real-time 3-dimensional echocardiographic parameters in a healthy Japanese population: The JAMP-3D study

journal contribution
posted on 2023-05-17, 23:25 authored by Fukuda, S, Watanabe, H, Daimon, M, Abe, Y, Hirashiki, A, Hirata, K, Ito, H, Iwai-Takano, M, Iwakura, K, Izumi, C, Hidaka, T, Yuasa, T, Murata, K, Nakatani, S, Kazuaki Negishi, Nishigami, K, Nishikage, T, Ota, T, Hayashida, A, Sakata, K, Tanaka, N, Yamada, S, Yamamoto, K, Yoshikawa, J

Background: The recently developed real-time 3-dimensional echocardiography (RT3DE) is a promising imaging method to quantify cardiac chamber volumes and their functions in clinical practice. However, normal reference values of RT3DE parameters have not been fully investigated in a large, healthy Japanese population.

Methods and Results: This study consisted of 410 healthy subjects aged from 20 to 69 years who had a RT3DE at one of the 23 collaborating institutions. All subjects had no history of cardiac disease and no risk factors. The mean values in men and women were as follows: 50 ± 12ml/m2 and 46 ± 9ml/m2 for left ventricular (LV) end-diastolic volume index, 19 ± 5ml/m2 and 17 ± 4ml/m2 for end-systolic volume index, 61 ± 4% and 63 ± 4% for ejection fraction, 64 ± 12g/m2 and 56 ± 11g/m2 for mass index, 23 ± 6ml/m2 and 24 ± 6ml/m2 for left atrial (LA) maximum volume index, 10 ± 3ml/m2 and 10 ± 3ml/m2 for minimum volume index, and 58 ± 6% and 58 ± 6% for percent volume change. LV sizes decreased with age, whereas LV mass index did not change. LA sizes slightly increased with age.

Conclusions: This multicenter investigation determined normal reference values for LV and LA sizes, and their functional parameters on RT3DE in a large, healthy Japanese population. The results of the present study support the use of RT3DE for the diagnosis and management of cardiovascular disease.


Publication title

Circulation Journal










Menzies Institute for Medical Research


Blackwell Publishing Asia

Place of publication

54 University St, P O Box 378, Carlton, Australia, Victoria, 3053

Rights statement

Copyright 2012 The Japanese Circulation Society

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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