University Of Tasmania

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Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease

journal contribution
posted on 2023-05-18, 14:26 authored by Venigalla, M, Sonego, S, Gyengesi, E, Matthew SharmanMatthew Sharman, Munch, G
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by deposition of amyloid plaques and neurofibrillary tangles, as well as microglial and astroglial activation, and, finally, leading to neuronal dysfunction and death. Current treatments for AD primarily focus on enhancement of cholinergic transmission. However, these treatments are only symptomatic, and no disease-modifying drug is available for the treatment of AD patients. This review will provide an overview of the antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of a variety of nutraceuticals including curcumin, apigenin, docosahexaenoic acid, epigallocatechin gallate, α-lipoic acid and resveratrol and their potential for AD prevention and treatment. We suggest that therapeutic use of these compounds might lead to a safe strategy to delay the onset of AD or slow down its progression. The continuing investigation of the potential of these substances is necessary as they are promising compounds to yield a possible remedy for this pervasive disease.


Publication title

Neurochemistry International








School of Health Sciences


Pergamon-Elsevier Science Ltd

Place of publication

United Kingdom

Rights statement

Copyright 2015 Elsevier Ltd.

Repository Status

  • Restricted

Socio-economic Objectives

Evaluation of health and support services not elsewhere classified