University Of Tasmania

File(s) under permanent embargo

Nutritional compounds influence tissue factor expression and inflammation of chronic kidney disease patients in vitro

journal contribution
posted on 2023-05-17, 04:43 authored by Shing, CM, Adams, MJ, Fassett, RG, Coombes, JS
OBJECTIVE: Nutritional compounds that potentially limit inflammation and tissue factor expression may decrease the progression of chronic kidney disease (CKD) and associated cardiovascular disease. This project aimed to determine the effect of curcumin, bovine colostrum, and fish oil on inflammatory cytokine and tissue factor procoagulant activity of peripheral blood mononuclear cells (PBMCs) from patients with CKD before dialysis. METHODS: Peripheral blood mononuclear cells from patients with CKD before dialysis (n = 13) and age- and sex-matched healthy controls (n = 12) were cultured alone and with low and high doses of the nutritional compounds for 24 h. Cells were cultured with and without lipopolysaccharide. Supernatants were analyzed for tumor necrosis factor-á, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1, IL-1â, C-reactive protein, and tissue factor procoagulant activity. RESULTS: The production of C-reactive protein, monocyte chemoattractant protein-1, IL-6, and IL-1â by PBMCs was inhibited by low- and high-dose fish oil in the CKD group (P < 0.05). Curcumin decreased secretion of IL-6 (P = 0.015) and IL-1 â (P = 0.016). Curcumin was more effective than colostrum at decreasing the procoagulant activity of PBMCs in the CKD and control groups (P < 0.019). CONCLUSION: Fish oil decreased inflammatory cytokine secretion from CKD PBMCs. In addition, the beneficial effects of curcumin were demonstrated in decreasing inflammation in vitro, often to a similar magnitude as fish oil.


Clifford Craig Foundation


Publication title

Nutrition: The International Journal of Applied and Basic Nutritional Sciences










School of Health Sciences


Elsevier Science Inc

Place of publication

360 Park Ave South, New York, USA, Ny, 10010-1710

Rights statement

The definitive version is available at

Repository Status

  • Restricted

Socio-economic Objectives

Diagnosis of human diseases and conditions

Usage metrics

    University Of Tasmania