University Of Tasmania
150902 - Obesity during childhood is associated with higher cancer mortality rate during adulthood.pdf (778.41 kB)
Download file

Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium

Download (778.41 kB)
journal contribution
posted on 2023-05-21, 09:14 authored by Nuotio, J, Laitinen, TT, Sinaiko, AR, Woo, JG, Urbina, EM, Jacobs, DR, Steinberger, J, Prineas, RJ, Sabin, MA, Burgner, DP, Minn, H, Burns, TL, Bazzano, LA, Alison VennAlison Venn, Viikari, JSA, Hutri-Kahonen, N, Daniels, SR, Raitakari, OT, Magnussen, CG, Juonala, M, Dwyer, T

Background: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce.

Methods: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3-19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries.

Results: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03-1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01-1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03-1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12-1.63).

Conclusions: Higher childhood BMI was independently associated with increased overall cancer mortality.


Publication title

International Journal of Obesity








Menzies Institute for Medical Research


Nature Publishing Group

Place of publication

United Kingdom

Rights statement

Copyright 2021 The Authors. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit

Repository Status

  • Open

Socio-economic Objectives

Overweight and obesity; Public health (excl. specific population health) not elsewhere classified