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Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination

journal contribution
posted on 2023-05-21, 12:08 authored by Daly, A, Martin, C, Sherriff, J, Mori, TA, Pereira, G, Lucas, RM, Ponsonby, A-L, Bruce TaylorBruce Taylor, Ingrid van der MeiIngrid van der Mei, Black, LJ
Higher intakes of omega-3 polyunsaturated fatty acids (n3PUFAs) have been associated with lower MS risk. We aimed to test associations between the Omega-3 Index, blood levels of n3PUFAs, fish oil supplement use, and fish consumption with a first clinical diagnosis of CNS demyelination (FCD). Cases (n, = 250) had a higher Omega-3 Index compared with a matched group of controls (n = 471) (average treatment effect (ATE)=0.31, p = 0.047, based on augmented inverse probability weighting). A higher percentage of cases than controls used fish oil supplements (cases=17% vs. controls=10%). We found that Omega-3 Index increased as time between FCD and study interview increased (e.g., at or below median (112 days), based on ATE, mean=5.30, 95% CI 5.08, 5.53; above median, mean=5.90, 95% CI 5.51, 6.30). Fish oil supplement use increased in a similar manner (at or below median (112 days), based on ATE, proportion=0.12, 95% CI 0.06, 0.18; above the median, proportion=0.21, 95% CI 0.14, 0.28). Our results suggest a behaviour change post FCD with increased use of fish oil supplements.


Publication title

Multiple Sclerosis and Related Disorders








Menzies Institute for Medical Research


Elsevier B. V.

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© 2021 Elsevier B.V.

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Socio-economic Objectives

Prevention of human diseases and conditions