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On-line sample concentration via micelle to solvent stacking of cations prepared with aqueous organic solvents in capillary electrophoresis

journal contribution
posted on 2023-05-17, 16:35 authored by Joselito Quirino, Aranas, AT
In this paper, by injecting a SDS micellar plug before the sample prepared in aqueous organic solvents, we show the on-line sample preconcentration of cations via micelle to solvent stacking (MSS) using solvents of as low as 30%. This extends the choice of stacking techniques to includemoderate amounts of organic solvent in the sample. The approach is akin to in-line solid phase extraction where the micellar plug acted as a transient micellar phase extractor. Basic studies were conducted (e.g. type and amount of organic solvent in the sample). The calculated sensitivity enhancement factors based on LOD obtained for the six test antipsychotic drugs were from 41 to 68. The peak signals were linear (R2 >0.99) from 0.2 to 10.0 ug/mL. The intraday and interday reproducibility (n = 10) for migration time, peak height, and corrected peak area were from 0.2 to 13.6%. The technique was also tested on spiked wastewater sample with minimal sample treatment (i.e. dilution and centrifugation).

History

Publication title

Electrophoresis

Volume

33

Issue

14

Pagination

2167-2175

ISSN

0173-0835

Department/School

School of Natural Sciences

Publisher

Wiley-V C H Verlag Gmbh

Place of publication

Po Box 10 11 61, Weinheim, Germany, D-69451

Rights statement

Copyright 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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