University of Tasmania
Browse

File(s) not publicly available

Oral cyclosporin plus topical corticosteroid therapy diminishes bone mass in children with eczema

journal contribution
posted on 2023-05-17, 02:29 authored by Pedreira, C, King, E, Graeme JonesGraeme Jones, Moore, E, Zacharin, M, Varigos, G, Cameron, F
Topical corticosteroids remain the most common treatment for eczema; however, it is uncertain whether long-term use of these agents has any adverse effect on bone mass. Cyclosporin is very useful in patients with severe atopic dermatitis who have failed conventional therapy. It has been shown to induce bone loss. We compared 43 children with severe eczema who were using topical corticosteroids with 73 healthy children. Of the 43 patients, six were also taking cyclosporin. Bone mineral density was measured in the lumbar spine and in the femoral neck using dual-energy X-ray absorptiometry. In multivariate analysis, subjects with eczema had lower lumbar spine bone mineral density (-0.03 g/cm2; p = 0.015) and bone mineral apparent density (-0.01 g/cm3; p = 0.008) but higher FN BMAD (+0.02 g/cm3; p = 0.029) compared with controls. Patients with eczema on topical corticosteroids who had used cyclosporin had lower lumbar spine bone mineral apparent density (-0.01; p = 0.006) compared with those only on topical corticosteroids in both adjusted and unadjusted analysis. In conclusion, children with severe eczema have decreased lumbar spine bone mass, which is primarily mediated by cyclosporin use rather than by topical corticosteroid use. This effect is likely to lead to a modest increase in the risk of wrist and forearm fractures in children using this agent.

History

Publication title

Pediatric Dermatology

Volume

24

Issue

6

Pagination

613-620

ISSN

0736-8046

Department/School

Menzies Institute for Medical Research

Publisher

Blackwell Publishing Inc

Place of publication

350 Main St, Malden, USA, Ma, 02148

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC