Oxidative DNA damage: Antioxidant response in postprandial hyperglycaemia in type 2 diabetes mellitus
journal contribution
posted on 2023-05-18, 04:16authored byAl-Aubaidy, HA, Jelinek, HF
The mechanism by which postprandial glucose load and sudden cardiac death are linked is not fully understood. This study compares the postprandial response of 8-hydroxy-deoxy-guanosine (8-OHdG)and erythrocyte glutathione (GSH) in control and type 2 diabetes groups. 8-OHdG was significantly elevated in type 2 diabetic patients (824.1±331.2 and 1087±273.1 pg/ml at the first and second hours respectively, p<0.05, versus 600.4±214.4 pg/ml at baseline) following a glucose load. This was associated with a significant reduction in the level of erythrocyte GSH after the first hour (59.1±9 mg/100ml; p<0.001) compared with the basal level (72.1±9 mg/100ml), followed by a significant elevation in the second hour (71.5±11.1 mg/100ml; p<0.001) compared with the first hour, bringing the GSH level only back to base level. The increase in 8-OHdG in people with type 2 diabetes during the postprandial period further supports previous evidence of a defective antioxidant response and greater risk of heart attack due to blood vessel endothelial cell damage and smooth muscle proliferation.
History
Publication title
The British Journal of Diabetes and Vascular Disease