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PD-L1 expression in papillary thyroid cancer with and without lymphocytic thyroiditis: a cross sectional study
journal contribution
posted on 2023-05-21, 12:00 authored by Fadia, M, Fookeerah, P, Ali, S, Shadbolt, B, Timothy GreenawayTimothy Greenaway, Perampalam, SThe impact of concurrent autoimmune thyroid disease on the tumour microenvironment and disease progression in papillary thyroid cancer (PTC) is not well understood. Studies evaluating the programmed cell death ligand 1 (PD-L1) tumour expression in PTC have shown variable results, and the effect of lymphocytic thyroiditis (LT) on tumour PD-L1 expression has not been adequately assessed. The main aim of this study was to determine expression of PD-L1 in PTC with and without LT. We examined 81 PTC cases; 28.5% of all reviewed PTC had presence of LT. In PTC specimens without LT, tumour PD-L1 expression was significantly lower compared to PD-L1 expression in PTC with LT, 6.9% vs 39.1%, respectively. Expression of PD-L1 did not differ with PTC stage, even when sub-categorised according to the presence and absence of LT. Utility of PD- L1 expression as a prognostic marker in thyroid cancer needs to be interpreted with caution.
History
Publication title
PathologyVolume
52Pagination
318-322ISSN
0031-3025Department/School
Tasmanian School of MedicinePublisher
Modern MedicinePlace of publication
Surry HillsRights statement
Crown Copyright © 2020 Published by Elsevier B.V. on behalf of Royal College of Pathologists of Australasia. All rights reserved.Repository Status
- Restricted