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PROactive 03: Pioglitazone, type 2 diabetes and reducing macrovascular events - economic implications?

journal contribution
posted on 2023-05-17, 09:27 authored by Bottomley, J, Andrew PalmerAndrew Palmer, Williams, R, Dormandy, J, Massi-Benedetti, M
Economic value of medicines, medical devices and other technologies is an increasingly important consideration in healthcare management. Conducting high quality economic analyses alongside randomised controlled clinical trials (RCTs) is desirable since these offer timely information with high internal validity. The recent publication of the landmark PROactive study provides a relevant platform upon which to base a detailed economic evaluation of the possible additional benefit of pioglitazone over and above current best treatment in patients with type 2 diabetes with severe cardiovascular (CV) disease. Pioglitazone improved CV outcome and reduced the need to add insulin to existing therapy in individuals at high risk of further macrovascular events. The predefined economic analysis of this study using well-accepted methods will inform the cost effectiveness (CE) of pioglitazone confirming (or not) its value in the management of patients with type 2 diabetes with severe CV disease.


Publication title

British Journal of Diabetes and Vascular Disease








Menzies Institute for Medical Research


Sage Publications Ltd.

Place of publication

United Kingdom

Repository Status

  • Restricted

Socio-economic Objectives

Evaluation of health and support services not elsewhere classified

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