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Palladium-mediated organic synthesis using porous polymer monolith formed in situ as a continuous catalyst support structure for application in microfluidic devices
journal contribution
posted on 2023-05-17, 01:03 authored by Anissa GoemannAnissa Goemann, Deverell, JA, Munting, KF, Jones, Roderick, Thomas RodemannThomas Rodemann, Allan CantyAllan Canty, Jason SmithJason Smith, Rosanne GuijtThe development and advantages of in situ synthesis of organic polymer monolith supports for metal pre-catalysts in narrow bore fused silica capillary microreactors are described. Catalyst immobilisation involves the covalent attachment of ligand binding sites to the porous polymer monolith, followed by coordination to metal centres. Flow-through microreactors using poly(chloromethylstyrene-co-divinylbenzene) monolith in capillaries of internal diameter 250 ìm were used successfully for Suzuki–Miyaura and Sonogashira reactions, utilising both 1,10-phenanthroline and imidazole/carbene binding to palladium and with very low palladium leaching, illustrating the potential of flow-through technology at the microscale level using organic monolith support for transition metal catalysed reactions.
Funding
Australian Research Council
History
Publication title
TetrahedronVolume
65Issue
7Pagination
1450-1454ISSN
0040-4020Department/School
School of Natural SciencesPublisher
Pergamon-Elsevier Science LtdPlace of publication
The Boulevard, Langford Lane, Kidlington, Oxford,Rights statement
The definitive version is available at http://www.sciencedirect.comRepository Status
- Restricted