University Of Tasmania

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Parallel comprehensive two-dimensional gas chromatography

journal contribution
posted on 2023-05-19, 14:00 authored by Yan, D, Tedone, L, Anthony KoutoulisAnthony Koutoulis, Whittock, SP, Robert ShellieRobert Shellie
We introduce an information rich analytical approach called parallel comprehensive two-dimensional gas chromatography (2GC × 2GC). This parallel chromatography approach splits injected samples into two independent two-dimensional column ensembles and provides two GC × GC separations by using contra-directional thermal modulation. The first-dimension (1D) and second-dimension (2D) columns are connected using planar three-port microchannel devices, which are supplied with supplementary flow via two pressure controller modules. Precise carrier gas flow control at the junction of the 1D and 2D columns permits independent control of flow conditions in each separation column. The 2GC × 2GC approach provides two entirely independent GC × GC separations for each injection. Analysis of hop (Humulus lupulus L.) essential oils is used to demonstrate the capability of the approach. The analytical performance of each GC × GC separation in the 2GC × 2GC experimentis comparable to individual GC × GC separation with matching column configurations. The peak capacity of 2GC × 2GC is about 2 times than that of single GC × GC system. The dual 2D chromatograms produced by this single detector system provide complementary separations and additional identification information by harnessing different selectivity provided by the four separation columns.


Publication title

Journal of Chromatography A








School of Natural Sciences


Elsevier Science Bv

Place of publication

Po Box 211, Amsterdam, Netherlands, 1000 Ae

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Copyright 2017 Elsevier B.V.

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Socio-economic Objectives

Expanding knowledge in the chemical sciences