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Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction

journal contribution
posted on 2023-05-17, 00:40 authored by Joanne DickinsonJoanne Dickinson, Perera, DI, Ingrid van der MeiIngrid van der Mei, Ponsonby, AL, Polanowski, AM, Russell Thomson, Bruce TaylorBruce Taylor, McKay, JD, Jim Stankovich, Terry DwyerTerry Dwyer
Multiple studies have provided evidence for an association between reduced sun exposure and increased risk of multiple sclerosis (MS), an association likely to be mediated, at least in part, by the vitamin D hormonal pathway. Herein, we examine whether the vitamin D receptor (VDR), an integral component of this pathway, influences MS risk in a population-based sample where winter sun exposure in early childhood has been found to be an important determinant of MS risk. Three polymorphisms within the VDR gene were genotyped in 136 MS cases and 235 controls, and associations with MS and past sun exposure were examined by logistic regression. No significant univariate associations between the polymorphisms, rs11574010 (Cdx-2A> G), rs1 0735810 (FoklT> C), or rs731236 (Taq1 C > T) and MS risk were observed. However, a significant interaction was observed between winter sun exposure during childhood, genotype at rsl1574010, and MS risk (P = 0.012), with the 'G' allele conferring an increased risk of MS in the low sun exposure group (~2 h/day). No significant interactions were observed for either rs10735810 or rs731236, after stratification by sun exposure. These data provide support for the involvement of the VDR gene in determining MS risk, an interaction likely to be dependent on past sun exposure. Multiple Sclerosis 2009; 15: 563-570. http://msj.sagepub.com

History

Publication title

Multiple Sclerosis

Volume

15

Issue

5

Pagination

563-570

ISSN

1352-4585

Department/School

Menzies Institute for Medical Research

Publisher

Arnold

Place of publication

Hodder Headline Plc, 338 Euston Road, London, England, Nw1 3Bh

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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