University Of Tasmania
149538 - Pathophysiology of circulating biomarkers and relationship with vascular aging.pdf (1.23 MB)
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Pathophysiology of circulating biomarkers and relationship with vascular aging: a review of the literature from VascAgeNet Group on circulating biomarkers, european cooperation in science and technology action 18216

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journal contribution
posted on 2023-05-21, 06:51 authored by Gopcevic, KR, Gkaliagkousi, E, Nemcsik, J, Acet, O, Bernal-Lopez, MR, Bruno, RM, Rachel ClimieRachel Climie, Fountoulakis, N, Fraenkel, E, Lazaridis, A, Navickas, P, Rochfort, KD, Satrauskiene, A, Zupkauskiene, J, Terentes-Printzios, D
Impairment of the arteries is a product of sustained exposure to various deleterious factors and progresses with time; a phenomenon inherent to vascular aging. Oxidative stress, inflammation, the accumulation of harmful agents in high cardiovascular risk conditions, changes to the extracellular matrix, and/or alterations of the epigenetic modification of molecules, are all vital pathophysiological processes proven to contribute to vascular aging, and also lead to changes in levels of associated circulating molecules. Many of these molecules are consequently recognized as markers of vascular impairment and accelerated vascular aging in clinical and research settings, however, for these molecules to be classified as biomarkers of vascular aging, further criteria must be met. In this paper, we conducted a scoping literature review identifying thirty of the most important, and eight less important, biomarkers of vascular aging. Herein, we overview a selection of the most important molecules connected with the above-mentioned pathological conditions and study their usefulness as circulating biomarkers of vascular aging.


National Health & Medical Research Council


Publication title

Frontiers in Physiology








Menzies Institute for Medical Research


Frontiers Research Foundation

Place of publication


Rights statement

Copyright 2021 Gopcevic, Gkaliagkousi, Nemcsik, Acet, Bernal-Lopez, Bruno, Climie, Fountoulakis, Fraenkel, Lazaridis, Navickas, Rochfort, Šatrauskien˙e, Zupkauskien˙e and Terentes-Printzios Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

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  • Open

Socio-economic Objectives

Prevention of human diseases and conditions