University of Tasmania
Browse

File(s) under permanent embargo

Patients with rheumatoid arthritis in the Australian OPAL cohort show significant improvement in disease activity over 5 years: a multicenter observational study

journal contribution
posted on 2023-05-18, 12:00 authored by Littlejohn, G, Roberts, L, Bird, P, de Jager, J, Griffiths, H, Nicholls, D, Young, J, Zochling, J, Tymms, KE

Objective: To evaluate disease activity trends in a large cohort of Australian patients with rheumatoid arthritis (RA) from 2009 to 2014.

Methods: This is a multicenter, cross-sectional, noninterventional study of patients with RA treated in Australia. Patients with RA treated at participating OPAL (Optimising Patient outcome in Australian RheumatoLogy) clinics were included in the study. Data, deidentified by patient, clinic, and clinician, were identified using a purpose-written electronic medical record. Patient demographics, disease onset, medications, and disease measures were analyzed. The Disease Activity Score at 28 joints (DAS28) was used to classify patients into the disease activity states of remission: low disease activity, moderate disease activity (MDA), and high disease activity. Choice of therapy was at the discretion of the treating clinician.

Results: At the time of analysis, the database contained 15,679 patients with RA, 8998 of whom fulfilled the inclusion criteria. Mean age was 63.2 years, mean disease duration was 13.8 years, and the majority were women (72.4%). A total of 37,274 individual DAS28-erythrocyte sedimentation rate scores were recorded for the 8998 patients. The frequency of remission increased significantly from 36.7% in 2009 to 53.5% in 2014 (p < 0.001), and that of MDA decreased from 33% (2009) to 22.2% (2014). The use of biologic disease-modifying antirheumatic drugs for the patients in remission increased from 17% in 2009 to 36.9% in 2014.

Conclusion: Contemporary management of RA in Australia shows improvements in disease activity toward the target of remission over a 5-year period.

History

Publication title

Journal of Rheumatology

Volume

42

Issue

9

Pagination

1603-1609

ISSN

0315-162X

Department/School

Menzies Institute for Medical Research

Publisher

J Rheumatol Publ Co

Place of publication

920 Yonge St, Suite 115, Toronto, Canada, Ontario, M4W 3C7

Rights statement

The Journal of Rheumatology © 2015. All rights reserved.

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC