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142504 - periaxonal and nodal plasticities.pdf (7.25 MB)

Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain

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journal contribution
posted on 2023-05-20, 20:28 authored by Carlie CullenCarlie Cullen, Pepper, RE, Clutterbuck, MT, Kimberley PitmanKimberley Pitman, Oorschot, V, Auderset, LF, Tang, AD, Ramm, G, Emery, B, Rodger, J, Jolivet, RB, Kaylene YoungKaylene Young
Central nervous system myelination increases action potential conduction velocity. However, it is unclear how myelination is coordinated to ensure the temporally precise arrival of action potentials and facilitate information processing within cortical and associative circuits. Here, we show that myelin sheaths, supported by mature oligodendrocytes, remain plastic in the adult mouse brain and undergo subtle structural modifications to influence action potential conduction velocity. Repetitive transcranial magnetic stimulation and spatial learning, two stimuli that modify neuronal activity, alter the length of the nodes of Ranvier and the size of the periaxonal space within active brain regions. This change in the axon-glial configuration is independent of oligodendrogenesis and robustly alters action potential conduction velocity. Because aptitude in the spatial learning task was found to correlate with action potential conduction velocity in the fimbriafornix pathway, modifying the axon-glial configuration may be a mechanism that facilitates learning in the adult mouse brain.


Australian Research Council

Australian National University


Publication title

Cell Reports








Menzies Institute for Medical Research


Cell Press

Place of publication

United States

Rights statement

Copyright 2020 The Authors. This is an open access article under the CC BY-NC-ND license

Repository Status

  • Open

Socio-economic Objectives

Expanding knowledge in the biomedical and clinical sciences

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