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Physical damage to rat cortical axons mimics early Alzheimer's neuronal pathology
journal contributionposted on 2023-05-16, 19:49 authored by Carolyn KingCarolyn King, Jacobs, I, Tracey DicksonTracey Dickson, James VickersJames Vickers
We investigated the reactive cytoskeletal changes following physical damage to axons in the rodent neocortex and compared these with the earliest neuronal alterations seen in Alzheimer's disease (AD). Insertion of a 25 gauge needle into the rodent somatosensory cortex resulted in ring- and club- like axonal changes characterized by an accumulation of neurofilaments. Morphologically and neurochemically identical abnormal axons were present within neocortical Î²-amyloid deposits of individuals in the early stages of AD. Physically damaged rat cortical axons may therefore serve as a model for the early neuronal pathology of AD. Furthermore, these results suggest that insoluble Î²-amyloid deposition may physically damage local axons, with further neurofibrillary changes due to the reactive neuronal response to this type of injury.
Department/SchoolMenzies Institute for Medical Research
PublisherLippincott Williams & Wilkins
Place of publicationUSA