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Potential role of flavonoids against sars-cov-2 induced diarrhea

journal contribution
posted on 2023-05-21, 12:11 authored by Alok PaulAlok Paul, Jahan, R, Bondhon, TA, Jannat, K, Hasan, A, Rahmatullah, M, Nissapatorn, V, Pereira, ML, Wiart, C
COVID-19, caused by the SARS-CoV-2 virus, can lead to massive inflammation in the gastrointestinal tract causing severe clinical symptoms. SARS-CoV-2 infects lungs after binding its spike proteins with alveolar angiotensin-converting enzyme 2 (ACE2), and it also triggers inflammation in the gastrointestinal tract. SARS-CoV-2 invades the gastrointestinal tract by interacting with Toll-like receptor-4 (TLR4) that induces the expression of ACE2. The influx of ACE2 facilitates cellular binding of more SARS-CoV-2 and causes massive gastrointestinal inflammation leading to diarrhea. Diarrhea prior to COVID-19 infection or COVID-19-induced diarrhea reportedly ends up in a poor prognosis for the patient. Flavonoids are part of traditional remedies for gastrointestinal disorders. Preclinical studies show that flavonoids can prevent infectious diarrhea. Recent studies show flavonoids can inhibit the multiplication of SARS-CoV-2. In combination with vitamin D, flavonoids possibly activate nuclear factor erythroid-derived-2-related factor 2 that downregulates ACE2 expression in cells. We suggest that flavonoids have the potential to prevent SARS-CoV-2 induced diarrhea.


Publication title

Tropical Biomedicine








School of Pharmacy and Pharmacology


Malaysian Society of Parasitology and Tropical Medicine

Place of publication


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© 2021. The Authors. Published by Malaysian Society of Parasitology and Tropical Medicine.

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Socio-economic Objectives

Prevention of human diseases and conditions

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