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Predictors of total hip replacement in community based older adults: a cohort study

journal contribution
posted on 2023-05-20, 23:29 authored by Mezhov, V, Laura LaslettLaura Laslett, Harbeer Ahedi, Christopher BlizzardChristopher Blizzard, Aspden, RM, Gregory, JS, Saunders, FR, Munugoda, IP, Guoqi CaiGuoqi Cai, Cicuttini, F, Graves, SE, Lorimer, M, Graeme JonesGraeme Jones

Objective: The purpose of this study is to describe predictors of total hip replacement (THR) in community dwelling older adults. A better understanding of predictors of THR can aid in triaging patients and researching preventative strategies.

Design: At baseline, participants had assessment of radiographic OA and cam morphology (from pelvic radiographs), shape mode scores and hip bone mineral density (BMD; from dual energy X-ray absorptiometry (DXA)). After 2.6 and 5 years, participants reported hip pain using WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index), and had hip structural changes assessed using magnetic resonance imaging (MRI). Risk of THR was analysed using mixed-effect Poisson regression.

Results: Incidence of THR for OA over 14 years was 4.6% (37/801). As expected, WOMAC hip pain and hip radiographic OA both predicted risk of THR. Additionally, shape mode 2 score (decreasing acetabular coverage) (RR 1.83 per SD; 95% CI 1.1–3.04), shape mode 4 score (non-spherical femoral head) (RR 0.59/SD; 95% CI 0.36–0.96), cam morphology (α > 60°) (RR 2.2/SD; 95% CI 1.33–3.36), neck of femur BMD (RR 2.09/SD, 95% CI 1.48–2.94) and bone marrow lesions (BMLs) increased risk of THR (RR 7.10/unit; 95% CI 1.09–46.29).

Conclusion: In addition to hip pain and radiographic hip OA, measures of hip shape, cam morphology, BMD and BMLs independently predict risk of THR. This supports the role of hip bone geometry and structure in the pathogenesis of end stage hip OA and has identified factors that can be used to improve prediction models for THR.


National Health & Medical Research Council


Publication title

Osteoarthritis and Cartilage

Article number

online ahead of print


online ahead of print




Menzies Institute for Medical Research


W B Saunders Co Ltd

Place of publication

32 Jamestown Rd, London, England, Nw1 7By

Repository Status

  • Restricted

Socio-economic Objectives

Diagnosis of human diseases and conditions

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