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Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species

Version 2 2024-09-18, 23:31
Version 1 2023-05-19, 03:23
journal contribution
posted on 2023-05-19, 03:23 authored by Bianca DeansBianca Deans, Just, J, Chhetri, J, Burt, LK, James Smith, Nathan KilahNathan Kilah, de Salas, M, Nuri GuvenNuri Guven, Alexander BissemberAlexander Bissember, Jason SmithJason Smith
The potential of a recently developed pressurized hot water extraction (PHWE) method employing an unmodified household espresso machine to facilitate rapid bioprospecting was investigated. A survey of some 16 Australian native plant species identified three Correa (Rutaceae) species containing significant quantities of coumarin natural products. As part of this study, seselin, (+)-epoxysuberosin, alosin, (–)-meranzin and heraclenin were isolated and, subsequently, used to synthesize the related natural products (+)-trachypleuranin A and (–)-yuehgesin B. In addition, seselin, (+)-epoxysuberosin, alosin, and (–)-meranzin were found to inhibit NQO1 activity. Interestingly, (–)-meranzin showed inhibitory activity comparable to the known potent NQO1 inhibitor dicoumarol.

History

Publication title

ChemistrySelect

Issue

8

Pagination

2439-2443

ISSN

2365-6549

Department/School

School of Natural Sciences

Publisher

Wiley - V C H Verlag GmbH & Co. KGaA

Place of publication

Germany

Rights statement

Copyright 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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