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Principal component and linkage analysis of cardiovascular risk traits in the Norfolk Isolate

journal contribution
posted on 2023-05-17, 08:31 authored by Cox, HC, Bellis, C, Lea, RA, Quinlan, S, Hughes, R, Dyer, T, Jac CharlesworthJac Charlesworth, Blangero, J, Griffiths, LR
Objective(s): An individual's risk of developing cardiovascular disease (CVD) is influenced by genetic factors. This study focussed on mapping genetic loci for CVD-risk traits in a unique population isolate derived from Norfolk Island. Methods: This investigation focussed on 377 individuals descended from the population founders. Principal component analysis was used to extract orthogonal components from 11 cardiovascular risk traits. Multipoint variance component methods were used to assess genome-wide linkage using SOLAR to the derived factors. A total of 285 of the 377 related individuals were informative for linkage analysis. Results: A total of 4 principal components accounting for 83% of the total variance were derived. Principal component 1 was loaded with body size indicators; principal component 2 with body size, cholesterol and triglyceride levels; principal component 3 with the blood pressures; and principal component 4 with LDL-cholesterol and total cholesterol levels. Suggestive evidence of linkage for principal component 2 (h(2) = 0.35) was observed on chromosome 5q35 (LOD = 1.85; p = 0.0008). While peak regions on chromosome 10p11.2 (LOD = 1.27; p = 0.005) and 12q13 (LOD = 1.63; p = 0.003) were observed to segregate with principal components 1 (h(2) = 0.33) and 4 (h(2) = 0.42), respectively. Conclusion(s): This study investigated a number of CVD risk traits in a unique isolated population. Findings support the clustering of CVD risk traits and provide interesting evidence of a region on chromosome 5q35 segregating with weight, waist circumference, HDL-c and total triglyceride levels.

History

Publication title

Human Heredity: International Journal of Human and Medical Genetics

Volume

68

Pagination

55-64

ISSN

0001-5652

Department/School

Menzies Institute for Medical Research

Publisher

Karger

Place of publication

Allschwilerstrasse 10, Basel, Switzerland, Ch-4009

Rights statement

Copyright © 2009 S. Karger AG,

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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