University Of Tasmania
150996 - Prophylactic Cefazolin Dosing in Obesity.pdf (1.31 MB)
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Prophylactic cefazolin dosing in obesity - a systematic review

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journal contribution
posted on 2023-05-21, 09:23 authored by Coates, M, Shield, A, Gregory PetersonGregory Peterson, Hussain, Z
Currently, there is no consensus on whether a standard 2-g prophylactic cefazolin dose provides sufficient antimicrobial coverage in obese surgical patients. This systematic review analysed both outcome and pharmacokinetic studies, aiming to determine the appropriate cefazolin dose. A systematic search was conducted using 4 databases. In total, 3 outcome and 15 pharmacokinetic studies met the inclusion criteria. All 3 outcome studies concluded that there is no need for increased dose. Also, 9 pharmacokinetic studies reached this conclusion; however, 6 pharmacokinetic studies recommended that 2-g dose is insufficient to achieve adequate plasma or tissue concentrations. The stronger body of evidence supports that 2-g dose of cefazolin is sufficient for surgery lasting up to 4 h; however, large-scale outcome studies are needed to confirm this evidence.


Publication title

Obesity Surgery










School of Pharmacy and Pharmacology


Springer New York LLC

Place of publication

United States

Rights statement

© The Author(s) 2022 This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, ( which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

Repository Status

  • Open

Socio-economic Objectives

Efficacy of medications