University Of Tasmania

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Pros and cons of pharmacological manipulation of cGMP-PDEs in the prevention and treatment of breast cancer

journal contribution
posted on 2023-05-23, 00:04 authored by Di Iorio, P, Ronci, M, Giuliani, P, Caciagli, F, Ciccarelli, R, Vanni CarusoVanni Caruso, Beggiato, S, Zuccarini, M
The cyclic nucleotides, cAMP and cGMP, are ubiquitous second messengers responsible for translating extracellular signals to intracellular biological responses in both normal and tumor cells. When these signals are aberrant or missing, cells may undergo neoplastic transformation or become resistant to chemotherapy. cGMP-hydrolyzing phosphodiesterases (PDEs) are attracting tremendous interest as drug targets for many diseases, including cancer, where they regulate cell growth, apoptosis and sensitization to radio- and chemotherapy. In breast cancer, PDE5 inhibition is associated with increased intracellular cGMP levels, which is responsible for the phosphorylation of PKG and other downstream molecules involved in cell proliferation or apoptosis. In this review, we provide an overview of the most relevant studies regarding the controversial role of PDE inhib-itors as off-label adjuvants in cancer therapy.


Publication title

International Journal of Molecular Sciences








School of Pharmacy and Pharmacology


Molecular Diversity Preservation International

Place of publication

Matthaeusstrasse 11, Basel, Switzerland, Ch-4057

Repository Status

  • Restricted

Socio-economic Objectives

Treatment of human diseases and conditions

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