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Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease
journal contributionposted on 2023-05-17, 17:34 authored by Cui, H, Freeman, C, Glenn JacobsonGlenn Jacobson, David SmallDavid Small
Proteoglycans (PGs) are major components of the cell surface and extracellular matrix and play critical roles in development and maintenance of the central nervous system (CNS). PGs are a family of proteins, all of which contain a core protein to which glycosaminoglycan side chains are covalently attached. PGs possess diverse physiological roles, particularly in neural development, and are also implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). The main functions of PGs in the CNS are reviewed as are the roles of PGs in brain injury and in the development or treatment of AD.
Publication titleIUBMB Life
Department/SchoolMenzies Institute for Medical Research
Place of publication325 Chestnut St, Suite 800, Philadelphia, USA, Pa, 19106