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Quantitative urinary excretion of unmetabolised N tau-[Me-C-14]methylhistidine by the common ringtail possum (Pseudocheirus peregrinus) Marsupialia
journal contributionposted on 2023-05-16, 10:10 authored by Watson, S, Foley, W, Stuart McLeanStuart McLean, Brandon, S, Noel DaviesNoel Davies
Six common ringtail possums (Psewbcheirus peregrinus) were intravenously injected with a standard dose of radioactive 3-Methylhistidine (N’-[Me-‘4C]MeH). The dose was rapidly and quantitatively excreted by the possums. More than 90% of radioactivity was recovered within 3 days. Thin layer chromatography and mass spectroscopy showed that 97% of recovered radioactivity was associated with unmetabolised N’-[Me-14C)MeH. These data satisfy two key requirements for the validity of urinary 3-Methylhistidine (Nr-3MeH) excretion as an index of muscle protein catabolism in P. peregrinus.
Publication titleComparative Biochemistry and Physiology. A: Physiology
Department/SchoolSchool of Pharmacy and Pharmacology
Place of publicationUSA
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