Random forest with self-paced bootstrap learning in lung cancer prognosis

Training gene expression data with supervised learning approaches can provide an alarm sign for early treatment of lung cancer to decrease death rates. However, the samples of gene features involve lots of noises in a realistic environment. In this study, we present a random forest with self-paced learning bootstrap for improvement of lung cancer classification and prognosis based on gene expression data. To be specific, we proposed an ensemble learning with random forest approach to improving the model classification performance by selecting multi-classifiers. Then, we investigated the sampling strategy by gradually embedding from high- to low-quality samples by self-paced learning. The experimental results based on five public lung cancer datasets showed that our proposed method could select significant genes exactly, which improves classification performance compared to that in existing approaches. We believe that our proposed method has the potential to assist doctors for gene selections and lung cancer prognosis.