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Rare and unique adaptations to cancer in domesticated species: An untapped resource?
journal contributionposted on 2023-05-21, 13:00 authored by Thomas, F, Giraudeau, M, Dheilly, NM, Gouzerh, F, Boutry, J, Beckmann, C, Biro, PA, Rodrigo Hamede RossRodrigo Hamede Ross, Abadie, J, Labrut, S, Bieuville, M, Misse, D, Bramwell, G, Schultz, A, Le Loc'h, G, Vincze, O, Roche, B, Renaud, F, Russell, T, Ujvari, B
Strong and ongoing artificial selection in domestic animals has resulted in amazing phenotypic responses that benefit humans, but often at a cost to an animal's health, and problems related to inbreeding depression, including a higher incidence of cancer. Despite high rates of cancer in domesticated species, little attention has been devoted to exploring the hypothesis that persistent artificial selection may also favour the evolution of compensatory anticancer defences. Indeed, there is evidence for effective anti-cancer defences found in several domesticated species associated with different cancer types. We also suggest that artificial selection can favour the "domestication" of inherited oncogenic mutations in rare instances, retaining those associated to late and/or less aggressive cancers, and that by studying these seemingly rare anticancer adaptations, novel cancer treatments may be found.
Publication titleEvolutionary Applications
Department/SchoolSchool of Natural Sciences
Place of publicationHoboken
Rights statement© 2020 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/) which permits use, distribution and reproduction in any medium, provided the original work is properly cited.