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Redox mechanisms in regulation of adipocyte differentiation: beyond a general stress response

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posted on 2023-05-19, 10:52 authored by Guei-Sheung LiuGuei-Sheung Liu, Chan, EC, Higuchi, M, Dusting, GJ, Jiang, F
In this review, we summarize advances in our understanding of redox-sensitive mechanisms that regulate adipogenesis. Current evidence indicates that reactive oxygen species may act to promote both the initiation of adipocyte lineage commitment of precursor or stem cells, and the terminal differentiation of preadipocytes to mature adipose cells. These can involve redox regulation of pathways mediated by receptor tyrosine kinases, peroxisome proliferator-activated receptor γ (PPARγ), PPARγ coactivator 1α (PGC-1α), AMP-activated protein kinase (AMPK), and CCAAT/enhancer binding protein β (C/EBPβ). However, the precise roles of ROS in adipogenesis in vivo remain controversial. More studies are needed to delineate the roles of reactive oxygen species and redox signaling mechanisms, which could be either positive or negative, in the pathogenesis of obesity and related metabolic disorders.

History

Publication title

Cells

Issue

4

Pagination

976-993

ISSN

2073-4409

Department/School

Menzies Institute for Medical Research

Publisher

MDPIAG

Place of publication

Switzerland

Rights statement

© 2012 by the authors. Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0) https://creativecommons.org/licenses/by/3.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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