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Redox mechanisms of the beneficial effects of heme oxygenase in hypertension

journal contribution
posted on 2023-05-19, 10:52 authored by Chan, EC, Dusting, GJ, Guei-Sheung LiuGuei-Sheung Liu, Jiang, F
Heme oxygenases, namely heme oxygenase-1 and heme oxygenase-2, have important biological functions in vascular homeostasis. Heme oxygenase and its catabolic products, including bilirubin and carbon monoxide, have been implicated in blood pressure regulation. Increased expression of heme oxygenase exerts multiple protective actions against hypertension-induced vascular injuries. However, the underlining mechanisms of these effects are not entirely clear. We and others have demonstrated that heme oxygenase-1 can modulate production of reactive oxygen species, both in vivo and in vitro, from NADPH oxidase, a major enzymatic source of reactive oxygen species generation in the vascular wall. NADPH oxidase has been implicated in the development of hypertension and hypertension-related organ injuries. In this mini review, we summarize our current understanding of the interactions between heme oxygenase and NADPH oxidase, and we propose that modulation of NADPH oxidase activity by heme oxygenase could be a potential mechanism of the beneficial effects of heme oxygenase in hypertension.

History

Publication title

Journal of Hypertension

Volume

32

Issue

7

Pagination

1379-1386

ISSN

0263-6352

Department/School

Menzies Institute for Medical Research

Publisher

Lippincott Williams & Wilkins

Place of publication

530 Walnut St, Philadelphia, USA, Pa, 19106-3621

Rights statement

Copyright 2014 Wolters Kluwer Health

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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