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Reduction of a platinum (IV) prodrug model by sulfur containing biological reductants: computational mechanistic elucidation

journal contribution
posted on 2023-05-19, 21:20 authored by Chipman, A, Brian YatesBrian Yates, Allan CantyAllan Canty, Alireza AriafardAlireza Ariafard
A PtIV prodrug needs to be reduced to PtII by a biomolecule in order to show efficacy. Among biomolecules, those containing an ʟ-Cys residue have the highest potential to be involved in reduction. Tautornerisation from HSCH2CH(NH3+)CO2¯ to the unusual zwitterion form ¯SCH2CH(NH3+)CO2H is the prerequisite for ʟ-Cys to become a potent reductant at a low pH.

History

Publication title

Chemical Communications

Volume

54

Issue

74

Pagination

10491-10494

ISSN

1359-7345

Department/School

School of Natural Sciences

Publisher

Royal Soc Chemistry

Place of publication

Thomas Graham House, Science Park, Milton Rd, Cambridge, England, Cambs, Cb4 0Wf

Rights statement

Copyright 2018 The Royal Society of Chemistry

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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    University Of Tasmania

    Categories

    Keywords

    platinum drugsanticancerDFTamino acidscysteinemethionine

    Licence

    In Copyright

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