University Of Tasmania

File(s) under permanent embargo

Regional respiratory inflation and deflation pressure-volume curves determined by electrical impedance tomography

journal contribution
posted on 2023-05-17, 21:10 authored by Frerichs, I, Peter DargavillePeter Dargaville, Rimensberger, PC
Measurement of regional lung volume changes during a quasi-static pressure-volume (PV) manoeuvre using electrical impedance tomography (EIT) could be used to assess regional respiratory system mechanics and to determine optimal ventilator settings in individual patients. Using this approach, we studied regional respiratory system mechanics in healthy and lung-injured animals, before and after surfactant administration during inflation and deflation PV manoeuvres. The comparison of the EIT-derived regional PV curves in ventral, middle and dorsal regions of the right and left lungs showed not only different amounts of hysteresis in these regions but also marked differences among different landmark pressures calculated on the inflation and deflation limbs of the curves. Regional pressures at maximum compliance as well as the lower and upper pressures of maximum compliance change differed between the inflation and deflation and increased from ventral to dorsal regions in all lung conditions. All these pressure values increased in the injured and decreased in the surfactant treated lungs. Examination of regional respiratory system mechanics using EIT enables the assessment of spatial and temporal heterogeneities in the ventilation distribution. Characteristic landmarks on the inflation and especially on the deflation limb of regional PV curves may become useful measures for guiding mechanical ventilation.


Publication title

Physiological Measurement










Menzies Institute for Medical Research


IOP Publishing Ltd

Place of publication

Dirac House, Temple Back, Bristol, England, Bs1 6Be

Rights statement

Copyright 2013 Institute of Physics and Engineering in Medicine

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified