University Of Tasmania

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Regulation of microvascular flow and metabolism: An overview

journal contribution
posted on 2023-05-19, 00:44 authored by Michelle Keske, Renee RossRenee Ross, Russell, RD, Blackwood, SJ, Brown, AA, Hu, D, Dino PremilovacDino Premilovac, Stephen RichardsStephen Richards, Stephen RattiganStephen Rattigan
Skeletal muscle is an important site for insulin to regulate blood glucose levels. It is estimated that skeletal muscle is responsible for ~80% of insulin-mediated glucose disposal in the post-prandial period. The classical action of insulin to increase muscle glucose uptake involves insulin binding to insulin receptors on myocytes to stimulate glucose transporter 4 (GLUT 4) translocation to the cell surface membrane, enhancing glucose uptake. However, an additional role of insulin that is often under-appreciated is its action to increase muscle perfusion thereby improving insulin and glucose delivery to myocytes. Either of these responses (myocyte and/or vascular) may be impaired in insulin resistance, and both impairments are apparent in type 2 diabetes, resulting in diminished glucose disposal by muscle. The aim of this review is to report on the growing body of literature suggesting that insulin-mediated control of skeletal muscle perfusion is an important regulator of muscle glucose uptake and that impairment of microvascular insulin action has important physiological consequences early in the pathogenesis of insulin resistance. This work was discussed at the 2015 Australian Physiological Society Symposium "Physiological mechanisms controlling microvascular flow and muscle metabolism".


Publication title

Clinical and Experimental Pharmacology and Physiology








Menzies Institute for Medical Research


Blackwell Publishing Asia

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Rights statement

Copyright 2016 John Wiley & Sons Australia, Ltd

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  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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