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Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes
journal contribution
posted on 2023-05-17, 23:48 authored by Fogarty, RD, Abhary, S, Javadiyan, S, Kasmeridis, N, Petrovsky, N, Whiting, MJ, Craig, JE, Kathryn BurdonKathryn BurdonAsymmetric dimethylarginine (ADMA) levels are elevated in diabetes and likely contribute to diabetic complications such as retinopathy and nephropathy. The DDAH enzymes are primarily responsible for ADMA metabolism. Polymorphisms in the dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes have been previously associated with serum ADMA levels in type 2 diabetes (T2DM). We sought to determine whether they are also associated with ADMA levels in individuals with type 1 diabetes (T1DM). Serum ADMA concentrations were measured in 196 individuals with T1DM. Twenty-six tag SNPs in the DDAH1 gene and 10 in the DDAH2 gene were genotyped. One SNP in the DDAH1 gene (rs3738111) and one in the DDAH2 gene (rs805293) showed a correlation with serum ADMA levels; however, neither survived correction for multiple testing. We found limited evidence that genetic polymorphisms in DDAH genes influence serum ADMA levels in individuals with T1DM. This differs to findings in T2DM and may be due to underlying differences in the cohorts or to fundamental differences in the pathogenesis of the two types of diabetes.
History
Publication title
Journal of Diabetes and Its ComplicationsVolume
26Pagination
195-198ISSN
1056-8727Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier Science IncPlace of publication
360 Park Ave South, New York, USA, Ny, 10010-1710Repository Status
- Restricted