Retinitis pigmentosa is an incurable degenerative disease that causes loss of light sensitive cells in the retina and leads to severe vision impairment. The development of optogenetics has created great hype around its potential to treat retinitis pigmentosa by the introduction of light sensitive proteins into other neural cells in the retina. The first in human studies of optogenetic treatment for this disease have recently been reported. The treatment involves irreversible gene therapy and requires access to specially designed goggles to deliver light to the treated eye. This highly innovative and high profile clinical trial raises numerous ethical issues that must be addressed during the early phases of research and clinical testing to ensure trial participants are treated fairly and can provide appropriate informed consent.