posted on 2023-05-18, 23:49authored byMeier, MH, Gillespie, NA, Hansell, NK, Alexander HewittAlexander Hewitt, Hickie, IB, Lu, Y, McGrath, J, MacGregor, S, Medland, SE, Sun, C, Wong, TY, Wright, MJ, Zhu, G, Martin, NG, David MackeyDavid Mackey
Mounting evidence suggests that individuals with schizophrenia have an underlying vulnerability to cardiovascular disease, and a recent study suggested that this vulnerability might be reflected in the retinal microvasculature. The purpose of this study was to test the hypothesis that the retinal microvessels reflect familial vulnerability to psychotic symptoms. Participants were 531 adolescent and young adult twins who took part in the Brisbane Longitudinal Twin Study and the Twins Eye Study in Tasmania. The twins had photographs taken of their retina when they were adolescents or young adults (M age=20.6 years), and retinal vessel diameter was assessed using computer software. The twins completed an assessment of psychosis symptoms approximately six years later. We compared retinal venular diameters of individuals with one or more symptoms of psychosis (n=45), their unaffected co-twins (n=24), and controls (n=462). Individuals with one or more symptoms of psychosis had wider venules (standardized mean=0.29) than controls (standardized mean=-0.04; p=.03), and unaffected co-twins had venular diameters that were intermediate (standardized mean=0.13) between the two groups, suggesting that wide venules may represent a proxy marker of familial vulnerability to psychosis symptoms. Consistent with previous work, there were no differences in arteriolar diameter between individuals with and without symptoms of psychosis. Findings suggest that wide retinal venules may serve as a proxy marker of familial liability to psychosis symptoms. The pathophysiological mechanisms linking psychosis and cardiovascular disease may be operative from early in life, possibly at the level of the microvasculature.
History
Publication title
Schizophrenia Research
Volume
164
Issue
1-3
Pagination
47-52
ISSN
0920-9964
Department/School
Menzies Institute for Medical Research
Publisher
Elsevier Science Bv
Place of publication
Po Box 211, Amsterdam, Netherlands, 1000 Ae
Rights statement
Copyright 2015 Published by Elsevier B.V. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/