76158 - Revisiting the role of acetylcholinesterase in Alzheimer's disease.pdf (1.11 MB)
Revisiting the role of acetylcholinesterase in Alzheimer's disease: cross-talk with P-tau and β-amyloid
journal contribution
posted on 2023-05-17, 10:42 authored by Garcia-Ayllon, MS, David SmallDavid Small, Avila, J, Saez-Valero, JA common feature in the Alzheimer's disease (AD) brain is the presence of acetylcholinesterase (AChE) which is commonly associated with â-amyloid plaques and neurofibrillary tangles (NFT). Although our understanding of the relationship between AChE and the pathological features of AD is incomplete, increasing evidence suggests that both â-amyloid protein (Aâ) and abnormally hyperphosphorylated tau (P-tau) can influence AChE expression. We also review recent findings which suggest the possible role of AChE in the development of a vicious cycle of Aâ and P-tau dysregulation and discuss the limited and temporary effect of therapeutic intervention with AChE inhibitors.
History
Publication title
Frontiers in Molecular NeuroscienceVolume
4Article number
22Number
22Pagination
45-53ISSN
1662-5099Department/School
Menzies Institute for Medical ResearchPublisher
Frontiers Research FoundationPlace of publication
SwitzerlandRights statement
Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/Repository Status
- Open