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Rod microglia and their role in neurological diseases

journal contribution
posted on 2023-05-20, 01:50 authored by Holloway, OG, Alison CantyAlison Canty, Anna KingAnna King, Jenna ZiebellJenna Ziebell
The striking morphology of microglia is one of their most prominent characteristics, with many studies categorising microglial function based on morphology e.g. ramified, hyper-ramified, activated, or amoeboid. Communications regarding rod microglia in neurological disease are scant, and where reported, these cells are rarely the focus of discussion. These factors make it difficult to determine how widespread these cells are not only through the brain but also across diseases. Studies in experimental diffuse brain injury are the first reports of not only significant numbers of rod microglia, but distinct arrangements of these cells, reminiscent of carriages of a train. This review summarises the available reports of rod microglia in vivo and rod-like microglia in vitro and eludes to possible functions and signalling cascades that may evoke this distinct morphology. More investigations are required to fully elucidate the function that rod microglia play in neurological diseases.

History

Publication title

Seminars in Cell and Developmental Biology

Volume

94

Pagination

96-103

ISSN

1084-9521

Department/School

Wicking Dementia Research Education Centre

Publisher

Academic Press Ltd Elsevier Science Ltd

Place of publication

24-28 Oval Rd, London, England, Nw1 7Dx

Rights statement

Copyright 2019 Elsevier Ltd.

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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