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Similar protein phosphatases control starch metabolism in plant and glycogen metabolism in mammals
journal contribution
posted on 2023-05-18, 11:22 authored by Niittyla, T, Comparot-Moss, S, Lue, W-L, Messerli, G, Trevisan, M, Seymour, MDJ, Gatehouse, JA, Villadsen, D, Steven SmithSteven Smith, Chen, J, Zeeman, SC, Smith, AMWereport that protein phosphorylation is involved in the control of starch metabolism in Arabidopsis leaves at night. sex4 (starch excess 4) mutants, which have strongly reduced rates of starch metabolism, lack a protein predicted to be a dual specificity protein phosphatase. We have shown that this protein is chloroplastic and can bind to glucans and have presented evidence that it acts to regulate the initial steps of starch degradation at the granule surface. Remarkably, themostclosely related protein to SEX4 outside the plant kingdom is laforin, a glucanbinding protein phosphatase required for the metabolism of the mammalian storage carbohydrate glycogen and implicated in a severe form of epilepsy (Lafora disease) in humans.
History
Publication title
Journal of Biological ChemistryVolume
281Issue
17Pagination
11815-11818ISSN
0021-9258Department/School
School of Natural SciencesPublisher
Amer Soc Biochemistry Molecular Biology IncPlace of publication
9650 Rockville Pike, Bethesda, USA, Md, 20814-3996Rights statement
© 2006 by The American Society for Biochemistry and Molecular BiologyRepository Status
- Restricted