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Skeletal muscle nitric oxide signaling and exercise: a focus on glucose metabolism
journal contribution
posted on 2023-05-17, 13:12 authored by McConell, GK, Stephen RattiganStephen Rattigan, Lee-Young, RS, Wadley, GD, Merry, TLNitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and this link was the subject of a Nobel prize in 1998. However, NO also plays many other regulatory roles, including thrombosis, immune function, neural activity, and gastrointestinal function. Low concentrations of NO are thought to have important signaling effects. In contrast, high concentrations of NO can interact with reactive oxygen species, causing damage to cells and cellular components. A less-recognized site of NO production is within skeletal muscle, where small increases are thought to have beneficial effects such as regulating glucose uptake and possibly blood flow, but higher levels of production are thought to lead to deleterious effects such as an association with insulin resistance. This review will discuss the role of NO in skeletal muscle during and following exercise, including in mitochondrial biogenesis, muscle efficiency, and blood flow with a particular focus on its potential role in regulating skeletal muscle glucose uptake during exercise.
Funding
National Health & Medical Research Council
History
Publication title
American Journal of Physiology: Endocrinology and MetabolismVolume
303Pagination
E301-E307ISSN
0193-1849Department/School
Menzies Institute for Medical ResearchPublisher
Amer Physiological SocPlace of publication
9650 Rockville Pike, Bethesda, USA, Md, 20814Rights statement
Copyright 2012 the American Physiological SocietyRepository Status
- Restricted